The Most Common Nutrient Deficiencies

Abstract word cloud for Vitamin B12 with related tags and terms

(Dr. Mercola) Even when you eat a balanced, whole-food diet similar to the one presented in my nutrition plan, you may still fail to get the right balance of vitamins and minerals your body needs for optimal health. Because many factors contribute to your body’s ability to derive nutrients from the food you consume, you may eat a healthy diet and still lack proper nutrition.

Changes in animal feed, climate, farming and food-processing methods, soil conditions, water quality and weather patterns, as well as increased use of genetic engineering and toxic pesticides, can have a negative effect on the quality of food available.

Your age, genetics and health conditions such as digestive issues also impact your body’s ability to absorb nutrients from your food. Often, vitamin and mineral deficiencies can be difficult to identify because you may not develop symptoms until the deficiency has become quite pronounced.

Below, I comment on 10 of the most common nutrient deficiencies — ranging from vitamin A to zinc. As you review the list, take note of any deficiency symptoms that may apply to your current situation. Then, be sure to address any area of concern. In doing so, you will continue to protect and optimize your health.

No. 1: Vitamin D

The Harvard School of Public Health suggests an estimated 1 billion people worldwide have low vitamin D levels, with deficiencies noted across all age and ethnic groups.1 You are at risk of missing out on vitamin D from natural sun exposure if you spend most of your time indoors, use topical sunscreens or wear long clothing for religious reasons. The signs and symptoms of vitamin D deficiencyinclude:

Achy or broken bones

Because vitamin D helps your body absorb calcium, it plays a role in your bone health. Studies involving older adults have associated low vitamin D levels with an increased risk of falls and fractures.2

Age 50 or older

At age 50, your kidneys may become less effective at metabolizing inactive vitamin D into its active form. At age 70 and beyond, your body will produce about one-third less vitamin D through sun exposure than it did at younger ages.

Body mass index > 30

Because vitamin D is fat soluble, when your fat cells uptake it, less is available for use elsewhere in your body.3 For this reason, some experts recommend you increase your intake of vitamin D if you are obese.

Dark skin

Melanin, which determines your degree of skin pigmentation and protects your body from harmful ultraviolet radiation (UV), impairs your skin’s ability to produce vitamin D from sunlight. If you have darker skin, your body may need up to 10 times more sun exposure to produce adequate vitamin D as compared to a person who has lighter skin.

Feeling depressed or consistently having low energy

Thanks to the brain hormone serotonin, your mood automatically elevates when you are in the sun. Researchers examining the effects of vitamin D on the moods of 80 elderly patients found the ones with the lowest vitamin D levels were 11 times more likely to suffer from depression.4

Frequent colds and flu

A study done in Japan indicated schoolchildren taking 1,200 units of vitamin D per day during winter reduced their risk of contracting the flu by about 40 percent.5

Head sweating

One of the classic signs of vitamin D deficiency is a sweaty head. Excessive sweating in newborns due to neuromuscular irritability is still described as a common, early symptom of vitamin D deficiency.6

If you are experiencing any of these symptoms, get your vitamin D level tested immediately. Even if you are in good health, I recommend you have your level tested twice a year. The optimal vitamin D level for general health ranges between 40 to 60 nanograms per milliliter (ng/ml). The ideal way to raise your vitamin D is by regularly and sensibly exposing large amounts of your skin, such as your arms, back, chest and legs, to sunshine. Getting outdoors at or around solar noon is the best time to soak up the sun.

If for whatever reason you cannot get outdoors, or not frequently enough to receive sufficient UV exposure, consider taking an oral vitamin D3 supplement along with vitamin K2 and magnesium. The only way to determine your ideal maintenance dose of vitamin D is by measuring your blood level. As a general guideline, vitamin D experts recommend 4,000 IUs per day for adults, but that level applies only if you are already in the therapeutic range. If your levels are low, you may need to start with 8,000 IUs or more per day.

No. 2: Omega-3s

If you regularly consume fast food and other highly processed foods, you probably overconsume inflammatory omega-6 fats. Such high consumption of omega-6s very likely means you may not be consuming enough of the healthier omega-3 fats. Processed foods — everything from frozen meals to salad dressings — are generally loaded with omega-6s, due to the vegetable oils used to make them.

Check labels carefully and do your best to avoid products containing corn, cottonseed, soybean, safflower and sunflower oils. If you are a regular consumer of fast food, be advised most of it is prepared with these same oils. Your recommended omega-6 to omega-3 balance should be close to a 1-to-1 ratio. However, because omega-6s are overabundant in the typical American diet, your ratio may be around 20-to-1, or as high as 50-to-1! It all depends on your eating habits.

Very often, when omega-6s predominate your diet, you will almost always suffer from inflammation and higher production of body fat. I suspect the high incidence of cancer, diabetes, heart disease, hypertension, obesity and premature aging noticeable worldwide may have its roots in the chronic inflammation resulting from this profound omega-3-to-omega-6 mismatch.

Omega-3s are anti-inflammatory and vital for supporting your brain function, joints, skin and vision, as well as your heart.7,8,9 They are derived from both plant and animal sources:

  • Alpha-linolenic acid (ALA): found in plant sources such as chia, flaxseeds, hemp and walnuts
  • Docosahexaenoic acid (DHA): found in animal sources such as anchovies, salmon and sardines, as well as fish oil supplements; alternatives to fish oil include algae and my personal favorite, krill oil
  • Eicosapentaenoic acid (EPA): also found in animal sources such as fish and fish oil, because wherever you find DHA, EPA is also there

I recommend an animal-based omega-3 because most of its cellular health benefits are linked to EPA and DHA, not the plant-based ALA. Although plant-based omega-3s are beneficial, and ideally you need both sources of omega-3, your focus should mainly be on the animal-based variety. To learn more about the critical differences between plant- and animal-based omega-3, and why they are not interchangeable, please see “The Critical Differences Between Omega-3 Fats From Plants and Marine Animals.”

In terms of supplementation, I believe krill oil is superior to fish oil. The omega-3 in krill is attached to phospholipids, which increase its absorption. Furthermore, compared to fish oil, krill oil contains almost 50 times more astaxanthin, a potent antioxidant that helps prevent omega-3s from oxidizing before they can be integrated into your cellular tissues. I cannot stress enough the importance of getting your omega-3 level tested.

No. 3: Magnesium

Because magnesium is the fourth most abundant mineral in your body, a deficiency can wreak havoc on your health. The fact researchers10 have detected more than 3,750 magnesium-binding sites on human proteins should give you a sense of how important this mineral is for your body’s optimal functioning. Your body needs magnesium for:

  • Activating muscles and nerves
  • Creating energy in your body by activating adenosine triphosphate (ATP)
  • Helping digest proteins, carbohydrates and fats
  • Serving as a building block for RNA and DNA synthesis
  • Acting as a precursor for neurotransmitters like serotonin

Dietary sources of magnesium include avocados, Brazil nuts, brown rice, cashews, dark leafy greens like spinach and Swiss chard, oily fish, raw cacao, seaweed and seeds. Since there is no simple routine blood test to determine your magnesium level, it is best to get a magnesium RBC test, while also carefully evaluating and tracking your symptoms. You may be suffering from magnesium insufficiency if you experience:

  • Constipation
  • Eye twitches, muscle spasms — especially “charley horses” or spasms in your calf muscle that occur when you stretch your legs, numbness or tingling in your extremities and seizures
  • Headaches and/or migraines
  • High blood pressure, heart arrhythmias and/or coronary spasms
  • Low energy, fatigue and/or loss of appetite

A few years ago, I interviewed Dr. Carolyn Dean, who has been studying magnesium for nearly 20 years. In her book, “The Magnesium Miracle,” Dean lists 100 factors to help you determine if you might be deficient. She also writes a blog, and you may find her post entitled “Gauging Magnesium Deficiency Symptoms” to be helpful.11 Check out the short video below by Dean to learn more about why your body can’t live without magnesium.

No. 4: Iodine

Iodine is an essential mineral found in every one of your organs and tissues. Your body needs iodine for normal thyroid function, including the production of thyroid hormones, which support brain development, bone maintenance, growth and metabolism. Nearly one-third of the world’s population is iodine deficient.12 Severe iodine deficiency can affect your child’s brain function and IQ. The most common symptoms you are not getting enough iodine include:

  • Dry mouth, dry skin and lack of sweating
  • Enlarged thyroid gland, also known as goiter, which contributes to a variety of cancers, including esophageal, breast, ovarian and thyroid
  • Increased heart rate
  • Shortness of breath
  • Weight gain

Dietary sources of iodine include eggs, fish, raw milk, spirulina and sea vegetables such as kelp, kombu, nori and wakame. If you take an iodine supplement, be aware of the potentially serious risks associated with taking too much iodine. As a general rule, I do not advise taking large doses of iodine supplements like Iodora or Lugol’s long term.

In the video below, Dr. Jorge Flechas, a family physician from North Carolina who specializes in iodine therapy for thyroid and breast disorders, provides an informative overview of your thyroid, the incidence of thyroid problems and the importance of intaking sufficient iodine.

No. 5: Zinc

While you may think about it mainly during cold and flu season, zinc is an essential mineral found throughout your organs, tissues and bodily fluids. Moreover, after iron, zinc is the second most abundant trace mineral in your body. Because zinc is vital to many biological processes, you may not realize your body does not store zinc. Instead, you must intake it daily through the foods you eat or a high-quality supplement. Zinc supports your body’s critical processes such as:

Blood clotting Immune function Smell, taste and vision
Cell division Thyroid health Wound healing

At least 2 billion people worldwide are thought to be zinc deficient, including about 12 percent of the U.S. population and as much as 40 percent of the elderly.13 Part of the deficit likely results from soil depletion due to conventional farming methods, as well as the use of toxic pesticides such as Roundup. Beyond the soil concerns, many simply do not eat enough zinc-rich foods, the mineral is often poorly absorbed, levels are infrequently checked and testing methods are often inaccurate.

Dietary sources of zinc include dairy products, nuts, red meat and seafood. Plant sources such as asparagus, beans, green peas and spinach also contain zinc, but it is more easily absorbed from meat and animal proteins.

If you are an alcoholic or vegetarian, are pregnant or lactating, or have a digestive disorder or sickle cell disease, you are more likely to have a zinc deficiency. Even if you consider yourself to be a healthy person, you may not be eating enough zinc-rich foods on a daily basis to achieve optimal levels of this essential nutrient.

In the video above, I discuss the importance of zinc to your health, the signs of zinc deficiency and how you may improve your zinc levels through your dietary choices. Vegetarians have a particular challenge as phytic acid in grains compete with the absorption of zinc and other nutrients, which doesn’t occur in meat and dairy sources of zinc.

If you have symptoms of a zinc deficiency and choose to use a supplement, make sure it’s from a reputable company using best-practice, quality assurance methods. Independent verification of the raw materials is vital to confirm quality and assure it is free of lead and other heavy metals. The supplement should contain several different types of zinc, such as gluconate, citrate and chelate. Unless your clinician recommends otherwise, don’t go above 40 mg per day.

No. 6: Vitamin B12

Vitamin B12 (cobalamin) is known as the energy vitamin, and you need it for blood formation, DNA synthesis, energy production and myelin formation. You may be deficient in vitamin B12 if you are not eating enough of the foods containing it, or your body lacks the ability to absorb it properly.

According to the U.S. Department of Agriculture, nearly 40 percent of the American population may have marginal vitamin B12 status14— not low enough to qualify as deficiency, but low enough to where certain neurological symptoms may start to appear. Warning signs of a B12 deficiency are slow to appear, so you may be quite deficient by the time you recognize the symptoms, which include:

Apathy Memory problems and/or “mental fog” Muscle weakness
Fatigue Mood swings Tingling in the extremities

Vitamin B12 is present in its natural form only in animal sources of food, such as:

  • Grass fed beef and beef liver
  • Lamb
  • Venison
  • Organic pastured eggs and poultry
  • Seafood such as salmon, scallops, shrimp and snapper

If you are a strict vegetarian or vegan, you are at increased risk of B12 deficiency. While you can get some B12 from coconut oil, fortified coconut milk and nutritional yeast, you may need to take a daily supplement. Chronic long-term B12 deficiency can lead to serious conditions such as dementia, depression and fertility problems.

Most B12 supplements sold today are a waste of your money because B12 does not absorb well. Your best option is to supplement with a B12 spray, which I think is better than receiving painful B12 shots from your doctor. Whether you choose animal foods or a high-quality spray, if you are a vegan, you should consider increasing your consumption of B12 to avoid future health problems.

No. 7: Vitamin E

Vitamin E is an important fat-soluble vitamin and antioxidant designed to combat inflammation and make red blood cells. It also helps your body use vitamin K, which is important for heart health. Six billion people worldwide and 75 to 90 percent of Americans are deficient in vitamin E.15 If you are among them, you are at increased risk for cardiovascular disease, cognitive deterioration and immune dysfunction.

To achieve an optimal level, you need at least 50 IUs of vitamin E daily. The recommended dietary allowance for anyone 14 years or older is 15 milligrams (mg) per day. Vitamin E is well-known for protecting against free radical damage and the effects of aging. It is actually a family of at least eight fat-soluble antioxidant compounds, divided into two main categories:

  • Tocopherols, which are considered the “true” vitamin E
  • Tocotrienols, each of which has subfamilies of four different forms

Vitamin E can easily be obtained from a healthy diet, and high amounts of it are found in three general categories of foods:

  • Leafy greens like spinach
  • High-fat foods such as nuts, seeds, fatty fish and seafood, including sardines and shrimp
  • Oil-rich, high-fat plants such as avocados and olives

Most of these foods are best eaten raw because cooking will destroy some of the nutrients. Obvious exceptions exist of course — do not eat raw shrimp, for example. If you must use a supplement, choose a full-spectrum vitamin E containing mixed natural tocopherols and tocotrienols. Avoid the synthetic form. Natural vitamin E is always listed as the “d-” form: d-alpha-tocopherol, d-beta-tocopherol, etc. Synthetic versions are listed as “dl-” forms.

No. 8:  Vitamin K2

Vitamin K is a fat-soluble vitamin that is well-known for its role in blood clotting. However, there are two different kinds of vitamin K,16each providing its own set of health benefits. Vitamin K1 is primarily responsible for blood clotting whereas vitamin K2 works synergistically with calcium, magnesium and vitamin D to impart a number of important health benefits.

Vitamin K2 also plays a crucial role in bone health,17 and may be critical for the prevention of osteoporosis (brittle bones). Osteocalcin is a protein produced by your osteoblasts (cells responsible for bone formation), and is utilized within the bone as an integral part of the bone-forming process. However, osteocalcin must be “carboxylated” before it can be effective. Vitamin K functions as a cofactor for the enzyme that catalyzes the carboxylation of osteocalcin.

If you do not have sufficient amounts of vitamin K2, you run the risk of both brittle bones and calcification in your soft tissues. In other words, vitamin K2 is necessary to keep your bones strong and your soft tissues pliable. A number of Japanese trials have shown that vitamin K2 completely reverses bone loss and in some cases even increases bone mass in people with osteoporosis.18

The pooled evidence of seven Japanese trials also show that vitamin K2 supplementation produces a 60 percent reduction in vertebral fractures and an 80 percent reduction in hip and other non-vertebral fractures.19 One Chinese meta-analysis20 of 19 randomized controlled trials found that vitamin K2 supplementation significantly improved vertebral bone density in postmenopausal women and reduced the risk of bone fractures.

Another three-year-long placebo-controlled study21 done in the Netherlands found that postmenopausal women taking 180 mcg of MK-7 per day increased their bone strength and saw a decrease in the rate of age-related bone mineral decline and reduced loss of bone density, compared to those taking a placebo. The following graphic, from a 2014 research paper22 on vitamin K2, illustrates the dual effect of vitamin K on bone and vascular health.

Vitamin K2 is found primarily in animal-based foods (MK-4) and fermented foods (MK-7). However, when it comes to MK-7, it’s important to realize that not all bacteria make K2, so only certain fermented foods will contain it. Grain fed animals will also produce far lower amounts of K2, and are best avoided for other reasons. Only grass fed animals will develop naturally high K2 levels.

For these reasons, most commercial yogurts are virtually devoid of vitamin K2, and while certain types of cheeses, such as Gouda, brie and Edam are high in K2, others are not. One of the best ways to get plenty of vitamin K2 from your diet it is to regularly eat home-fermented vegetables made with a special starter culture designed with bacterial strains that produce vitamin K2.

You can get up to 500 mcg of vitamin K2 in a 2-ounce serving of fermented vegetables using such a starter culture, which is a clinically therapeutic dose. This is also one of your most economical alternatives.

No. 9: Selenium

Selenium serves two very important and interrelated roles:

  1. At the cellular level, selenium is an active component of glutathione peroxidase, an enzyme that converts hydrogen peroxide to water. Glutathione peroxidase has potent antioxidant properties, and serves as a first line of defense against build-up of harmful free radicals in your cells.
  2. Selenium also plays an important role in the prevention of cancer. One of the reasons people get cancer is because of excessive free radical production. By reducing free radicals, selenium helps reduce your risk of cancer.

If you like Brazil nuts, eating about two to three of them per day will typically be sufficient. If you opt for a supplement, make sure to get the correct form. What you’re looking for is the high-selenium yeast form, the scientifically tested and most recommended version.

No. 10: Vitamin A

Nearly half of American adults and teens are at risk for insufficiency or deficiency of vitamin A.23 Your body needs a daily dose of this fat-soluble vitamin to maintain healthy bones, cell membranes, immune function, skin, teeth and vision. Vitamins A and D work in tandem, and there’s evidence suggesting that without vitamin D, vitamin A can be ineffective or even toxic.

On the other hand, if you’re deficient in vitamin A, vitamin D cannot function properly either, so a balance of these two vitamins is essential to good health. That said, because we do not yet know the optimal ratios between these two vitamins, balancing them well through supplementation can be challenging. For that reason, if you are able, it’s best to intake vitamins A and D from food and sun exposure, rather than supplements.

The best source of vitamin A your body can actually use is animal products such as fish, grass fed meat, liver and pastured poultry, as well as raw, organic dairy products like butter. These foods contain retinol, preformed vitamin A that your body can easily use. You will find it difficult to get sufficient amounts of vitamin A from beta-carotene, a provitamin A found in plant foods like broccoli, cantaloupe, carrots, squash and sweet potatoes.

While your body can readily use the retinol form of vitamin A, it must convert provitamin A (carotenoids) into bioavailable retinol. If you’re in excellent health, this should not pose a major problem; however, factors such as alcohol use, digestive problems and genetics can affect your body’s ability to absorb carotenoids and convert them into retinol. Medical conditions that interfere with the digestion of fat, including Crohn’s disease, cystic fibrosis and gallbladder and liver disease also affect your body’s ability to convert vitamin A.

A number of studies have raised warnings about vitamin A supplementation; indicating high doses may lead to toxicity, and may raise your risk of cancer, heart disease and all-cause mortality. Be particularly cautious with retinol or retinoic acid supplements, as these fat-soluble forms pose a greater risk of toxicity. Strictly avoid all synthetic versions.

Most Milk Substitutes are Low in Iodine – Here’s Why it Matters

(The Conversation) Milk and dairy products are the main source of iodine in many diets, and an important iodine source in many countries. However, our latest research found that the iodine concentration of most alternatives to cows’ milk – such as soy and almond “milk” – is very low. This matters because deficiency of iodine, especially during pregnancy, affects brain development and is linked to lower intelligence.

As people increasingly switch from cows’ milk to alternative drinks, and their sales grow, we wanted to know if consumers of these products would be able to match the amount of iodine in cows’ milk. To do this we measured the iodine concentration of 47 milk substitutes available in the UK, including a range of different types: soya, almond, oat, rice, coconut, hazelnut and hemp (but excluding those marketed for infants and children).

Related: Homemade, Vegan Nut Milk Recipes and More

We found that most milk substitutes were naturally low in iodine; their concentration was around 2% of that of cows’ milk. And only three of the 47 drinks were fortified with iodine. While some manufacturers replace the calcium found in cows’ milk, the vast majority, including big brands, do not replace the iodine.

We are aware that consumers may choose these alternatives for a variety of reasons, including allergy or intolerance to cows’ milk, so it is important that they are aware of the low iodine content of milk substitutes and the potential health consequences.

Iodine matters

Most people don’t know that iodine is found in cows’ milk and are unaware that they need a certain amount in their diet. In the UK, iodine is not listed on the nutrition information labels on milk containers, and there is little knowledge that iodine intake matters – even among pregnant women.

Cows’ milk is an excellent source of iodine, with a glass (200g) providing around 70μg (micrograms), a considerable proportion of the 150μg iodine intake recommended for European adults every day. By contrast, our study found that a glass of milk substitute would provide only around two micrograms.

The drinks with added iodine (as stated on the ingredients label) provided a reasonable amount of iodine (between 45μg and 60μg per glass). But, as these drinks were not from a market leader, most consumers will probably not get enough iodine in their diet from this source.

Severe iodine deficiency during pregnancy is well known to cause impaired brain development and lead to lower IQ in the infant. It is for that reason that many countries have added iodine to table salt (iodised salt) in order to improve iodine intake and reduce the impact of deficiency on population health. As a result, the number of countries with severe iodine deficiency has been reduced, but some countries are still classified as mildly-to-moderately iodine deficient.

But as our earlier research has shown, even mild-to-moderate iodine deficiency in pregnant women is linked to lower IQ and reading scores in their children, up to nine years of age.

Other dietary sources

Of course, milk is not the only source of iodine. Other rich sources include seafood – particularly white fish, such as cod. Eggs are also a good source of iodine.

Cod is a good source of iodine. TunedIn by Westend61/Shutterstock

For people who cannot or will not eat these alternative sources – such as vegans or those who dislike fish – it can be hard to meet the recommended iodine intake. Some people may, therefore, need to consider a suitable iodine supplement to ensure that their intake is adequate.

Related:  Four Easy Ways to Improve Your Thyroid Function

It is very important that kelp supplements – often sold as an iodine source in health food shops – are not used, as they can provide excessive amounts of iodine.

Unfortunately, there is no test for iodine deficiency. To know if you’re getting enough iodine, you need to consider whether iodine sources are part of your diet. We have written a fact sheet on iodine, available through the British Dietetic Association, that can help you understand how to meet the recommendations.

How to Help Heal Mental Disorders With Nutrition

(Dr. Mercola) Can you use specific nutrients to improve your mental health? Yes, you can. William Walsh, Ph.D., president of the nonprofit Walsh Research Institute in Naperville, Illinois, and author of “Nutrient Power: Heal Your Biochemistry and Heal Your Brain,” specializes in nutrient-based psychiatry and nutritional medicine.

He and I are both  fellows of the American College of Nutrition. He’s designed nutritional programs for Olympic athletes, NBA players and major league baseball players. More importantly, he’s spent a great deal of his career seeking to improve mental health through nutrition.

“I started off in the hard science. I was an experimentalist,” Walsh says. “I worked, in the beginning, in the nuclear field … with places like Los Alamos, the Institute for Atomic Research and University of Michigan Research Institute. I wound up at Argonne National Laboratory. While working as a scientist there, I started a volunteer project at the local prison, Stateville Penitentiary.

I eventually got really interested in why people were violent …  [W]hen we started the ex-offender program, I got to meet the families that had produced a criminal. I found some wonderful families, caring and capable families, that have other children who turned out just fine …

I began to realize we didn’t understand why people had bad behavior. We then asked the question, ‘Could it be something related to their brain chemistry or the body chemistry?’… I started doing lab studies of their blood, their urine and hair. I found out that they were very, very different from the rest of the population. That’s how I got started.”

Biochemistry and the Criminal Brain

Walsh received valuable direction after meeting Dr. Carl Pfeiffer, who was doing work on heavy metals and schizophrenia. As it turns out, levels of metals, including copper, zinc and manganese, were all abnormal in criminals compared to the general population.

Walsh discovered four biochemical types of violent people. One of these was the sociopaths, all of whom had severe zinc deficiency, pyrrole disorder, low blood spermine and undermethylation. In all, it’s an unusual combination of bad biochemistry. A collaborative investigation with Pfeiffer resulted in nutrient therapies for each of the behavior types.

Pyrrole disorder is a stress condition commonly found in brain disorders. A urine test developed by niacin expert Abram Hoffer and Pfeiffer is the gold standard test for this genetic condition, which involves altered  biochemistry in your bone marrow and spleen.

People who have pyrrole disorder may produce five to 10 times more pyrroles than normal — a byproduct of natural reactions, like the formation of hemoglobin. While harmless in and of itself, pyrroles bind to and draw out anything that is an aldehyde, such as B-6. It also sharply depletes zinc.

As a result, people with pyrroles disorder have exceptionally low levels of B-6, and zinc which can have serious effects on brain function, affecting their memory and ability to read, for example. B-6 deficiency is quite common among children with attention deficit hyperactivity disorder (ADHD) as well.

Related: Increase your IQ with the Right Foods, Herbs, Vitamins

The Earlier the Treatment the Better the Results

“Eventually, [Pfeiffer] and I jointly evaluated 500 patients, mostly violent adults and violent children. We got our best results with the kids, young people with the same kind of chemistry, who were mostly very violent,” Walsh says.

“I have to say we didn’t really succeed in finding a way to help the adult criminals. They would get better for six to eight months, and then I’d find out they were back in prison. That had a lot to do with the fact that they were abusing alcohol and illegal drugs … At about 1990, we decided to focus on children …

It’s been very successful. If we can get a child before their lives are ruined, before they pass puberty perhaps, our success rate [is] very high … The doctors report a striking improvement in behavior. Most of these kids, of course, [are] on drugs, everything from Ritalin to powerful antipsychotic  medications. Usually when we’re finished and [have] balanced their chemistry, they can wean off the medication. They usually are fine without it …”

Nutrients Involved in Synthesis or Functioning of Neurotransmitters Dictate Mental Function

Later on, Walsh expanded to also include children with autism and ADHD. Fond of numbers, Walsh began amassing enormous databases. At present, he has one of the world’s largest chemistry database for autismdepression and behavior disorders.

“When you look at these millions of chemical analyses of blood, urine and tissues, it’s obvious that there are very great differences,” he says. “I found that for mental disorders, about six or seven chemical imbalances dominate mental function. There are hundreds and hundreds of important nutrients in the body, but in the brain, there are about six or seven that [seem] to dominate everything. Eventually, I found out why …

[T]hese are the nutrient factors that are either involved in synthesis of a neurotransmitter or the functioning of a neurotransmitter. They include methylation — undermethylation or overmethylation. In our database, 70 percent of all humans in the United States have normal, typical methylation; 22 percent are undermethylated … 8 percent are overmethylated.

About 70 percent of all people who have a mental disorder have one of these methylation disorders. The symptoms are completely different, and the treatment they need is completely different. We also found that most people [who have mental disorders] are depleted or deficient in zinc. That’s the most common [deficiency] we see … Virtually everyone with a mental disorder seems to need zinc and improve on it.”

Copper Overload Linked to Autism, Schizophrenia and Postpartum Depression

Copper is another important trace metal, as it plays a distinct role in the synthesis of norepinephrine, a major neurotransmitter. Divalent copper (Cu2+) is a dramatic factor in the ratio of dopamine and norepinephrine.

Related: Autism, Gut Health, Obesity, the MMR Vaccine, and Andrew Wakefield

Animal studies have shown that when animals are starved of copper until they only have 25 percent of the normal amount of copper in their blood, the ratio between norepinephrine and dopamine is changed by more than a factor of three. Most of us have the ability to homeostatically control copper. However, some do not have that ability.

“It all has to do with an enzyme called metallothionein that is genetically expressed. Some people don’t have that system working,” Walsh explains. “These persons have copper overload, which we find virtually in every autistic patient, most patients with schizophrenia and almost everyone with postpartum depression.

That’s a recipe for very high norepinephrine — which means anxiety and depression — and low dopamine (a feel-good neurotransmitter), which is a hallmark of ADHD … a nasty combination.

We find the sociopaths innately have low copper levels. People who have undermethylation tend to have low normal copper levels … The good news for mental disorders is that there are more than 100 really important biochemicals in the body, but only a few dominate mental disorders.

If we had to do lab testing for 100 of them, it would be really difficult. If we had to adjust the levels of these and normalize 100 different factors, it would make life very difficult. But we found that by just focusing on maybe seven or eight nutrient factors, we could help 95 percent of the patients we see with nutrient therapy.”

How to Measure Your Zinc and Copper Status

Zinc experts typically agree that plasma zinc provides the most accurate measurement. The taste test has some minor value but is among the least reliable. To accurately measure copper, serum copper is the way to go, and most labs throughout the world provide good copper assays.

Walsh recommends doing a ceruloplasmin test at the same time, because then you can determine how much free radical copper you have, which gives you a good indication of your level of oxidative stress. A high sensitivity C-reactive protein (CRP) test would also be useful as a marker of inflammation.

“By the way, oxidative stress runs through every single mental disorder we see, without exception,” Walsh says. “Every one of them seems to have extraordinary oxidative stress — schizophrenia, bipolar disorder, a violent child or an autistic child.”

Unfortunately, our modern lifestyle strongly promotes oxidative stress, with processed foods, processed vegetable oils, excessive net carbs and excessive protein being some of the most potent factors. This kind of diet causes a reduction in ketones and a radical increase in reactive oxygen species and secondary free radicals.

Exposure to non-native electromagnetic fieldsglyphosate and other pesticides, fluoride-contaminated water and other toxic exposures only add to the problem. Typically, copper and ceruloplasmin levels tend to go hand in hand, being either high or low together. The ideal level for copper, with respect to mental health, is somewhere between 75 and 100 micrograms per deciliter (mcg/dL) in serum. The ideal amount of ceruloplasmin has to do with whatever your level of copper is.

Ideally, the percentage of copper in your ceruloplasmin should be around 85 to 90 percent. “It’s really great to do both simultaneously because then you have a really good picture of not only the copper situation, but also the level of oxidative stress,” Walsh says.

Related: Homemade Calcium and Magnesium

The Importance of Methylation in Mental Health

Walsh was among the first people to alert the world to the importance of methylation in mental health, especially autism. The No. 1 causes of undermethylation are single-nucleotide polymorphisms (SNPs) or mutations in the enzymes for the one-carbon cycle (the methylation cycle).

“The No. 1 factor is the methylenetetrahydrofolate reductase (MTHFR), which is one of the enzymes. That’s the rate-limiting step for that whole cycle, for most people,” Walsh explains. “Genetic testing services such as 23andMe can provide this kind of information.

However, most human beings have enormous numbers of SNPs. They’ve already found 10 million snips (or mutations) in the human genome. Every human being has thousands of these SNPs. A really high percentage of people have even the more serious MTHFR SNPs — the C677T, the A1298C that people are always talking about.

The thing that is often mistaken by nutritional scientists is that if a person has the homozygous, the double copies of the C677T, it doesn’t necessarily mean they’re undermethylated. It certainly doesn’t mean that they will benefit if you give them methylfolate. That’s one of the problems that we’re finding.

The reason is epigenetics. You have to consider the epigenetics and the methylation at the same time. There are three nutrient factors that affect epigenetics more than anything else: folates, methionine and S-adenosylmethionine (SAMe). These have a really powerful impact on epigenetics.”

How Folates Affect Epigenetics

Folates are serotonin reuptake promoters. However, even if an individual is undermethylated and has a problem related to low serotonin activity, such as depression or anxiety, folates should not be given, Walsh warns. The reason? If you give folate, their methylation will improve and the patient will actually get worse.

Related: Mental Health, Physical Health & B Vitamins – Nature’s Valium

The reason for this worsening is because, epigenetically, folates act as deacetylase inhibitors and sharply lower serotonin activity. Most autistic individuals will not have a serotonin problem and will thrive on methyl folate. However, an estimated 10 percent of autistic children and adults do have a serotonin issue and will severely regress if given methyl folate.

“We’ve had thousands of patients who were undermethylated depressives. I’ve seen more than 3,000 cases of clinical depression. I’ve got this huge database. The largest phenotype … is undermethylation.

But if you gave them any form of folate, they would get worse. Their methylation would improve, they would get worse, because it has a dramatic impact on serotonin reuptake. In contrast, methionine and SAMe are natural serotonin reuptake inhibitors.

They do essentially the same thing that Prozac and Paxil do. Folates have the opposite effect. Folates are wonderful if you want to knock dopamine level down in schizophrenics or people who have high anxiety — overmethylated people. It’s counterintuitive because folates are excellent methylating agents..”

To reiterate, some undermethylated people are intolerant to folates, and some overmethylated people thrive on folates even though folates improve methylation. As you can see, there are epigenetic complexities involved here, making self-diagnosis and self-treatment highly inadvisable.

It could be quite risky to take these bits and pieces of information and try to apply them on your own. There are simply too many variables. So, the bottom line here is to make sure you’re being treated by a knowledgeable professional.

Heavy Metals and the Autistic Brain

Walsh has tested 6,500 autistic patients. As a group, they have much higher toxic metal levels than their siblings or the general population. Walsh believes their toxic burden is likely due to an inborn predisposition that makes them more likely to accumulate toxins and/or vulnerable to the effects of toxins.

“Thousands of these parents, maybe more than half, told a very sad story of how they had a child who was developing normally, was beginning to speak and was singing and charming their grandparents. Then maybe the child got sick.

They took him to a pediatrician and the pediatrician — I’ve heard this story hundreds of times — said, ‘Oh, you’re behind on your shots. You’re behind on your vaccinations.’ They took a sick child and gave them multiple vaccinations, at that time, with thimerosal and mercury.

Hundreds of these families said that within a day or two, their child changed forever. Lost all speech, the personality changed, they became sick. They became intolerant to served foods. They were just very troubled little human beings.

When they went to specialists, eventually they wound up with the diagnosis of autism and were told that it was incurable and that there was no hope really for recovery. We’ve seen a lot of human misery just talking with these families. It’s just a shocking and terrible thing.”

Walsh suspects autistic children have an insufficiency of natural antioxidants such as glutathione and metallothionein, rendering them more vulnerable to the effects of environmental exposures, including vaccines and poor diet. It’s worth noting that 1 in 3 children diagnosed with autism does not have true autism caused by epigenetic variations.

Many of these children have a good chance of recovery, whereas classic Kanner autism is a permanent, life-long epigenetic condition (named after Leo Kanner, who discovered autism in the 1940s1), although some measure of improvement can be made even in these cases.

Related: How To Detoxify and Heal From Vaccinations – For Adults and Children

On Thimerosal

Walsh has also investigated the thimerosal issue, looking for evidence of mercury toxicity in the brains of autistic children. In fact, he was the first person to actually measure mercury in autistic brains.

He was able to receive brain tissue samples from Johns Hopkins, and using the Argonne facility called the Advanced Photon Source, he did over 1 million chemical analyses on brain tissue from autistic and non-autistic children. Every autistic child analyzed had received thimerosal-containing vaccinations.

However, no mercury could be found in the brain tissue. One explanation for this is that the tests were done years after the vaccinations. The half-life of mercury in the human body is 42 days. The half-life of ethyl or methyl mercury in the brain is 70 days.

“I think what it amounts to is that mercury is a terrible poison. It’s a terrible insult,” he says. “I think these vulnerable kids should never be exposed to it. However, it doesn’t stay in the body and it doesn’t do continuing damage. I think after a year or so, it has left the body, even though there are tens of thousands of families who are trying therapies that will take the mercury out of their child’s brain when it’s no longer there.”

Metallothionein Promotion Nutrient Therapy for Autism

The fact that autistic children tend to have extraordinary copper and zinc imbalances means their metallothionein protein is not functioning. Metallothionein is required for homeostatic control of copper and zinc. Walsh has developed a metallothionein promotion nutrient therapy: a formulation of 22 nutrients known to enhance genetic expression and function of metallothionein. This protocol has been used on more than 2,000 autistic patients, with measurable improvements in outcome.

“The most important antioxidants in the brain are somewhat different than the rest of the body. I call them the three musketeers. It’s glutathione, metallothionein and selenium. It’s specific to the brain,” he explains.

Technically, selenium is not an antioxidant per se, but it does increase glutathione levels and enhances the function of metallothionein and, in the brain, glutathione and metallothionein work together. Glutathione is your first line of defense. The problem is, autistic children typically have a poor diet (it’s hard to get them to eat anything) and with the oxidative overload, they quickly run out of glutathione. When you run low on glutathione in your brain, your metallothionein level increases.

“Metallothionein doesn’t work unless you have oxidized glutathione. It’s a hand in glove situation. It’s the backup system for glutathione in the brain, and we know that without selenium, that whole system doesn’t work well,” Walsh explains.

I take selenium every day. It’s a trace mineral, so you don’t need much, up to about 200 mcg per day, and you definitely need to be mindful not to overdose. As noted by Walsh, of all the trace metals, selenium has the narrowest division between deficiency and overload, so you need to be careful when supplementing.

Zinc also needs to be normalized, as it is the No. 1 factor for enabling metallothionein to function and support glutathione. According to Walsh, for mental and physical health, you need a plasma zinc level between 90 and 130 mcg/dL. Many mental patients have a genetic weakness in zinc normalization; they’re born with zinc deficiency, and need far higher amounts than typical to maintain a healthy zinc level.

Related: Total Nutrition – Make your own Homemade Multivitamin and Mineral Formula

Changing the Face of Psychiatry

Walsh is convinced the use of psychiatric medication will eventually fade away as we learn more about normalizing brain function through nutritional interventions. “These powerful drugs … they do not normalize the brain. They cause an abnormal condition,” he warns. “They might correct depression or anxiety, but you wind up with something that’s not normal.”

The Walsh Research Institute is a public charity with no financial interests, and they are slowly but surely helping to change mainstream psychiatry. Walsh has given talks at the highest levels, including the Surgeon General’s office, the U.S. Senate and the National Institutes of Health (NIH). He’s also spoken at American Psychiatric Association (APA) annual meetings several times.

“The last time I went there, they finally listened to me … I was there about two and a half years ago. I gave an invited talk on depression. I basically explained to them they’re doing depression wrong. They actually listened to me. I showed them our huge chemistry database and explained that depression is a name given to at least five completely different disorders, each involving different symptoms and each involving different neurotransmitters that are malfunctioning.

Then I described each one of these biotypes and actually showed them that if they would simply do some inexpensive blood and urine testing, they could identify which people would be good candidates for selective serotonin reuptake inhibitors (SSRIs) or which ones would do better on benzodiazepine, but even more importantly, how they can correct it with nutrients.”

There were 17,000 psychiatrists at this meeting from all over the world, and Walsh was 1 of 4 speakers at a well-attended session. Afterward, there was tremendous demand for more information, which gives hope. Walsh also offers a training program for doctors. In the U.S., 45 psychiatrists went through the program last year. In all, 500 physicians and psychiatrists in 32 countries have taken his program so far.

Why SSRIs Induce Violence

One major problem with SSRI antidepressants is the risk of self-harm and aggression as a side effect. Overmethylated, low-folate depressors are intolerant so SSRIs, and evidence suggests this genetic intolerance may have been a factor in many school shootings. Walsh, who has studied this phenomenon, notes 42 of the 50 major school shootings in the U.S. since 1990 were done by teens or young adults taking an SSRI.

“I discussed this … before the APA … I tried to explain to them that they … can do a blood test; they can find out which children or which adults are more likely to become violent if they get an SSRI. I’ve written about this several times; published it in magazines …

If you buy Prozac or Paxil, the insert inside warns that some people … are prone to suicidal or homicidal behavior. We now know which ones they are!”

More Information

To learn more, visit www.WalshInstitute.org. There you can also purchase Walsh’s book, “Nutrient Power: Heal Your Biochemistry and Heal Your Brain.” Questions and information requests can be sent to Dana@WalshInstitute.org, or you can call (630) 506-5066.

“Our website has a resources section that recommends quality labs, compounding pharmacies and a list of doctors who we’ve trained, who are now able to do this kind of therapy,” Walsh says.