Study Shows BPA Substitutes May Cause Same Health Issues As The Original

(The Conversation) The credibility of scientific findings hinges on their reproducibility. As a scientist, it is therefore disastrous when you are unable to replicate your own findings. Our laboratory has found itself in just this situation several times; in each instance, unintended environmental exposure distorted our data. Our first accidental foray into toxicology 20 years ago convinced us of the need to understand the reproductive effects of environmental chemical contaminants. The latest twist in our journey down that road adds a new dimension to an old concern, BPA.

Bisphenol A, or BPA, is a man-made chemical that has become a household word. It is a plasticizer used in such a wide range of consumer products that daily exposure is inevitable. People absorb BPA through our skin – from receipts and contamination of personal care products and water. We ingest it via contamination from plastic food containers, and food and beverage liners. We even inhale it as a contaminant in dust. Studies of this chemical number in the thousandsbut whether BPA is hazardous to our health remains “controversial.” Here’s why: Although data from traditional toxicology testing provide little or no evidence of harm, independent investigators like us have reported effects induced by very low doses thought to be in the realm of human exposure.

Related: How to Detox From Plastics and Other Endocrine Disruptors

The implications of these low-dose effects for human health and reproduction captured media attention and increased consumer unease. In response, manufacturers introduced BPA replacements by producing structurally similar bisphenols. As a result, it no longer is simply BPA contaminating our environment but an ever-increasing array of bisphenols. Our recent studies of several replacements suggest effects on the production of eggs and sperm similar to those induced by BPA.

We stumbled into the BPA world 20 years ago when cages housing mice for our studies were damaged when inadvertently washed with a detergent intended for the floor. Unbeknownst to us the detergent caused BPA to leach out of the cages. We happened to be studying eggs from young females and saw an immediate increase in eggs with scrambled chromosomes that would give rise to chromosomally abnormal embryos. In the intervening 20 years, our studies and those of colleagues have described the effects of BPA exposure on the developing brain, heart, lung, prostate, mammary gland and other tissuesand our studies have described serious effects on the production of both eggs and sperm. Together these findings inflamed debate about the safety of BPA and resulted in the rapid appearance of “BPA free” products.

Remarkably, almost exactly 20 years after the BPA exposure of our mice, we recently found ourselves, once again, victim of an environmental contamination that halted our research. We were working to pinpoint the critical windows of BPA exposure when we noticed that something was interfering with our experiments. This time the effect was harder to run to ground: Again, it appeared to be due to cage damage, but the damage was milder, limited to a subset of cages, and the effect on our results was evident in some animals and not others.

Related: Microplastics in Sea Salt – A Growing Concern

The major culprit this time was not BPA but the replacement bisphenol, BPS, leaching from damaged polysulfone caging. Knowing what it was didn’t make eliminating it easy. We tried several less expensive methods to solve the problem, but ultimately had to replace all the cages and water bottles in the facility. When we could resume our studies, we experimentally tested four common replacement bisphenols and found effects on sperm and egg production in our mice analogous to those that result from BPA exposure.

The possibility that exposure effects may span generations has been a growing concern. Our recent experience with accidental exposure allowed us to ask if BPS exposure effects persisted across generations, and if so, for how long. Our data suggest persistence of effects for up to three generations, with full recovery evident in great-grandsons.

Widespread use of BPA-like chemicals

Do we simply have bad lab karma? No, we think we have supersensory powers. The process of making eggs and sperm is tightly controlled by complex hormone signals. This makes it vulnerable to endocrine-disrupting chemicals like bisphenols – chemicals that can interfere with our body’s hormones. Bisphenol contaminants cause a seismic shift in our data, but it’s not that the research of others isn’t also affected, but most remain blissfully ignorant.

Importantly, our laboratory knew what data from unexposed animals should look like. What if we hadn’t? We would have misinterpreted our results. If we had been asking if BPA had an effect, background bisphenol contamination would have diminished it, causing us to conclude that BPA had little or no effect.

This isn’t merely hypothetical. BPA use is so prevalent in consumer products and routine laboratory materials (like mouse caging materials or culture flasks) that low-level contamination of unexposed control groups is increasingly difficult to avert. Data and conclusions from CLARITY-BPA, a large, ambitious collaborative study conducted by three U.S. agencies, are coming out now. CLARITY was launched to understand why findings from traditional toxicology studies of BPA and those of independent investigators differ. Animal contamination was evident in a pilot study, but the source could not be determined, and the CLARITY initiative proceeded.

Related: Many Hand-me-down Plastic Toys Are Toxic for Kids

Given our experience, we have great concern about drawing any conclusions from CLARITY data because there is no way to determine the impact of low-level contamination.

The bisphenol story details the evolution of only one class of the endocrine-disrupting chemicals that are common contaminants in our lives. The ability of manufacturers to rapidly modify chemicals to produce structurally similar replacements undermines the ability of consumers to protect themselves from hazardous chemicals and federal efforts to regulate them.

As a canary whose research has been twice derailed by bisphenols, we feel the need to chirp loudly: These contaminants may not only affect our health, but also our ability to conduct meaningful studies of chemicals to determine if and how they impact on our health and the environment.The Conversation

Patricia Hunt, Professor of Molecular Biosciences, Washington State University and Tegan HoranWashington State University

Warning—BPA-Free Plastic Containers May Be Just as Hazardous

In the past, plastic was thought of as an inert substance. Now we know that plastic chemicals can and do leach from plastic containers, thereby contaminating the foods and beverages they hold.

Among the most hazardous of these chemicals known to date are bisphenol-A (BPA) and phthalates, both of which mimic hormones in your body. Even tiny concentrations can cause problems, and you’re likely being exposed from a wide variety of sources.

Aside from canned goods, they’re found in reusable food containers, plastic wraps, water bottles, personal care products—you name it. In response to consumer demand for BPA-free products, many manufacturers have switched to using a different chemical called bisphenol-S (BPS).

Alas, BPS appears to be just as toxic, if not more so, than BPA… A Mother Jones report1 published earlier this year accused the plastics industry with using a tobacco-style campaign to bury findings linking their products with health problems. More recently, Scientific American2 noted that:

“BPS was a favored replacement because it was thought to be more resistant to leaching. If people consumed less of the chemical, the idea went, it would not cause any or only minimal harm.

Yet BPS is getting out. Nearly 81 percent of Americans have detectable levels of BPS in their urine. And once it enters the body it can affect cells in ways that parallel BPA.”

Health Hazards of BPA

BPA, which mimics the hormone estrogen, has been linked to a number of health concerns, including:

Structural damage to your brain Changes in gender-specific behavior, and abnormal sexual behavior
Hyperactivity, increased aggressiveness, and impaired learning Early puberty, stimulation of mammary gland development, disrupted reproductive cycles, ovarian dysfunction, and infertility3
Increased fat formation and risk of obesity Stimulation of prostate cancer cells
Altered immune function Increased prostate size and decreased sperm production

Endocrine Disrupting Chemicals Can Affect Sexual Development and Fertility

Ovarian toxicity appears to be a particularly strong feature of BPA. Harvard researchers have found that higher BPA levels in women are linked to a reduced number of fertile eggs. According to the New York Times:4

“The accumulating research fuels rising concern among scientists that childhood exposure to BPA may well contribute to female infertility, and that adult exposure may result in a shorter reproductive life span.

‘I think most scientists working today agree that BPA is an ovarian toxicant,’ Dr. Flaws said. A review of research into BPA, published this summer in the journal Environmental Health Perspectives,5 noted that ovarian toxicity is among the most consistent and strongest effects found ‘in both animal models and in women.’” 

Meanwhile, in Sweden, a rise in the number of boys born with deformed penises—a condition known as hypospadias—has researchers “stumped.” A notable increase appears in children born after 1990, nearly doubling compared to previous decades.6

Hypospadias is a birth defect in which the opening of the urethra is on the underside of the penis instead of at the end, which affects both urination and sexual function. Scientists are speculating whether endocrine disrupting chemicals such as BPA and phthalates may be at fault.

Researchers have also pointed out links between phthalates and infertility. A report in Chemical and Engineering News7 discusses recent findings8 suggesting a mechanism of action for this link. The researchers found that exposure to phthalates correlate with a biomarker for oxidative damage to DNA.

While this held true in both men and women, the effect was stronger in women. Women also had higher urine concentrations of all but one phthalate metabolite. Cosmetics are suspected of being the chief culprit, accounting for the different levels in men and women.

BPS Appears to Be Just as Harmful as BPA

As mentioned, many manufacturers are simply switching BPA for BPS, which allows them to slap the much-sought after “BPA-free” label on their wares. But BPS, it turns out, appears to have many of the same concerns as BPA.

Last year, researchers at the University of Texas Medical Branch discovered that even minute concentrations—less than one part per trillion—of BPS can disrupt cellular functioning. Metabolic disorders like obesity, diabetes, and even cancer, are potential ramifications of such disruptions.

Basically, while manufacturers are not lying by stating their products are “BPA-free,” they’re not necessarily telling the whole truth either. Many have simply traded one endocrine-disrupting chemical for another, and health-conscious consumers may be lulled into a false sense of security by the BPA-free label. According to the featured article:9

“A 2011 study published in Environmental Health Perspectives10 found that almost all of the 455 commercially available plastics that were tested leached estrogenic chemicals. 

This study lead to a bitter legal battle between Eastman Chemical Co. and the study’s author, George Bittner, professor of neurobiology at The University of Texas at Austin and founder of CertiChem and PlastiPure, two companies designed to test and discover nonestrogenic plastics.

Bittner claimed in the peer-reviewed report that Eastman’s product Tritan, marketed to be completely free of estrogenic leaching, showed such activity. 

Eastman claimed otherwise and filed a suit. A federal jury ruled in favor of the latter, saying Bittner’s testing methods were inadequate because the tests were done in vitro—in a petri dish rather than in vivo, in a live animal.”

Animal Tests Show BPS Affects Brain and Heart Function

Having learned their lesson, researchers are now focusing their investigations on live animal testing,11 and results show BPS is hardly a healthier alternative to BPA:

  • Researchers studying the effects of BPS on zebra fish embryos found that fish exposed to BPS in similar concentrations as that found in the water of a nearby river experienced explosive neuronal growth, which led to hyperactive and erratic behavior as the fish grew. Fish embryos exposed to BPS had a 170 percent increase in neuronal growth; while those exposed to BPA had a 240 percent increase.
  • Another study using rats found that exposure to either BPA or BPS caused heart arrhythmia in the females. Here, the dose used was similar to concentrations found in humans. The researchers discovered that BPS blocked an estrogen receptor found only in the females, which disrupted the calcium channels. This is also a common cause of heart arrhythmia in humans.

The root of the problem goes back to a lack of regulation—there’s no proper agency testing for toxicity before a chemical is allowed on the market. Banning BPS will not solve this problem, as there are many types of bisphenols, and simply switching from one to another is nothing but a game of toxic musical chairs. At present, you may be paying more for a “BPA-free” product that is no safer than the old BPA-containing variety… You’re also exposed to a number of other chemicals courtesy of food and beverage containers,12 most of which have no warning labels at all.

Another chemical high on the list of concern is styrene, found in Styrofoam cups. According to scientists with the National Research Council, styrene can be “reasonably anticipated to be a human carcinogen.”13 Heat and prolonged storage increases the leaching of most if not all of these plastic chemicals from their respective plastic containers, and this may be of particular concern when it comes to Styrofoam, as foam cups are almost exclusively used for hot drinks.

Phthalates: Industrial Strength Gender-Benders

Then of course there are the phthalates, which are used as plasticizers in everything from vinyl flooring to detergents and toys. This hormone disrupter can also be found in soaps, shampoos, and cosmetics of all kinds. They’re even used as food additives!14 Research has linked phthalates with the feminization of males of all species. These chemicals have disrupted the endocrine systems of wildlife, causing testicular cancer, genital deformations, low sperm counts, and infertility in polar bears, deer, whales, and otters, just to name a few. Scientists believe phthalates are responsible for a similar pattern in humans as well. As you can see, the effects of phthalate exposure, listed below, are very similar to that of bisphenols (BPA and BPS), which isn’t surprising considering they all affect your endocrine system and sex hormones:

Disturbed lactation “Decreased dysgenesis syndrome”: A syndrome involving cryptorchidism (undescended testicles), hypospadias, and oligospermia (low sperm count)
Interference with sexual differentiation in utero Enlarged prostate glands
Impaired ovulatory cycles and polycystic ovary disease (PCOS) Numerous hormonal disruptions
Early or delayed puberty Breast cancer, uterine fibroids, and testicular cancer

Chemical Industry Is Reusing the Tobacco Industry’s Playbook…

The Democracy Now video above reveals how the chemical industry uses the same playbook that the tobacco industry became notorious for. The only difference is that they have not been exposed yet, whereas the tobacco industry finally had to admit to the health hazards of its products. For example, many of the studies that found no adverse health effects of BPA were funded by the chemical industry, and as noted in the video, there’s a hidden network here; industry-funded studies get published in certain journals that in many cases have links to the tobacco industry. The chemical industry has also relied on scientists that previously helped discredit the science linking smoking and second-hand smoke exposure to disease.

So, not only has the chemical industry borrowed the tobacco industry’s strategies to keep their products on the market, they’re also relying on the tobacco industry’s “experts” to back up their safety claims. It is now a historical fact that the tobacco industry purposely buried evidence linking tobacco smoking to health problems such as lung cancer, and the chemical industry is now doing the exact same thing; using the same tactics and experts as the tobacco industry once relied on.

As an example, one chemical in particular became the focus of Mariah Blake’s investigation for Mother Jones: Tritan, made by Eastman Chemical. According to Blake, a number of independent scientists have tested this product, and found it has estrogenic activity—in fact, it is MORE estrogenic than polycarbonate, a BPA-containing plastic. Internal documents released during the course of a lawsuit against Eastman Chemical reveals that the company suppressed evidence showing that Tritan is in fact estrogenic. Shocking but true, there are about 80,000 chemicals used in various products sold in the US, and only a tiny fraction of them have undergone safety testing.

And, because of lack of regulation, when a chemical like BPA is taken out of production, the industry simply replaces it with another untested chemical… It’s like a never-ending vicious circle where as soon as one chemical is found to be hazardous, another takes its place and is allowed to wreak havoc for decades until someone realizes the hazard that one poses… As crazy as it sounds, the chemical industry is a largely unregulated field, and as such it poses a tremendous danger to human health. Leaked minutes from a 2009 meeting of the BPA Joint Trade Association are also revealing.

Members of this association include the American Chemical Council, the American Chemistry Council, Coca-Cola, Del Monte, and many others. In this meeting, they explored a variety of messaging strategies, including what they called “fear tactics.” An example of a fear tactic would be to use statements like “Do you want to have access to baby food anymore?” The attendees agreed that “the holy grail spokesperson” would be “a pregnant young mother who would be willing to speak around the country about the benefits of BPA.” As noted by Mariah Blake, one of the most disturbing aspects of the chemical industry’s efforts to hide hazardous effects is that they purposely target those who are the most vulnerable to damage, such as young children and pregnant women.

Tips to Reduce Your Exposure to Endocrine Disrupting Plastic Chemicals

To avoid any number of chemical toxins leaching into your food and beverages, choose glass over plastic, especially when it comes to products that will come into contact with food or beverages, or those intended for pregnant women, infants, and children. This applies to canned goods as well, which are a major source of BPA, so whenever you can, choose jarred goods over canned goods, or opt for fresh whole foods instead. I also recommend avoiding plastic teething toys for your little ones. Considering their pervasiveness, it may be next to impossible to avoid all sources of exposure to BPA, BPS, phthalates, and similar toxins, but you can certainly reduce your exposure dramatically by making more informed choices. To limit your exposure, please consider the following suggestions:

Only use glass baby bottles and dishes for your baby
Get rid of your plastic dishes and cups, and replace them with glass varieties
Give your baby natural fabric toys instead of plastic ones
Store your food and beverages in glass containers
If you choose to use a microwave, microwave food in glass containers, not plastic
Use glass, ceramic, or stainless steel travel coffee mugs rather than plastic or Styrofoam coffee cups
Avoid using plastic wrap (and never microwave anything covered in it)
If you opt to use plastic kitchenware, at least get rid of the older, scratched-up varieties, avoid putting them in the dishwasher, and don’t wash them with harsh detergents, as these things can cause more chemicals to leach into your food
Avoid using bottled water; filter your own using a reverse osmosis filter instead
Before allowing a dental sealant to be applied to your, or your children’s, teeth, ask your dentist to verify that it does not contain BPA