Future Dental Product May Cure Cavities

(Natural Blaze) Researchers at the University of Washington have designed a convenient and natural product that uses proteins to rebuild tooth enamel and treat dental cavities.

The “modern” theory of dental disease suggests that we have an almost total lack of power and responsibility concerning this condition. Children’s cavities are on the rise, and children today who have cavities are requiring more expensive and extensive dental surgery to hide the problems of dental decay.

Related: Three Homemade Toothpaste Recipes – Better Oral Health for Less Cost

The research finding was first published in ACS Biomaterials Science and Engineering.

“Remineralization guided by peptides is a healthy alternative to current dental health care,” said lead author Mehmet Sarikaya, professor of materials science and engineering and adjunct professor in the Department of Chemical Engineering and Department of Oral Health Sciences.

The new biogenic dental products can — in theory — rebuild teeth and cure cavities without today’s costly and uncomfortable treatments.

“Peptide-enabled formulations will be simple and would be implemented in over-the-counter or clinical products,” Sarikaya said.

Cavities are more than just a nuisance. According to the World Health Organization, dental cavities affect nearly every age group and they are accompanied by serious health concerns. Additionally, direct and indirect costs of treating dental cavities and related diseases have been a huge economic burden for individuals and health care systems.

Related: Periodontal Disease, Gum Disease – What you need to know (with recipes)

“Bacteria metabolize sugar and other fermentable carbohydrates in oral environments and acid, as a by-product, will demineralize the dental enamel,” said co-author Sami Dogan, associate professor in the Department of Restorative Dentistry at the UW School of Dentistry.

Although tooth decay is relatively harmless in its earliest stages, once the cavity progresses through the tooth’s enamel, serious health concerns arise. If left untreated, tooth decay can lead to tooth loss. This can present adverse consequences on the remaining teeth and supporting tissues and on the patient’s general health, including life-threatening conditions.

Good oral hygiene is the best prevention, and over the past half-century, brushing and flossing have reduced significantly the impact of cavities for many Americans. Still, some socio-economic groups suffer disproportionately from this disease, the researchers said. And, according to recent reports from the Centers for Disease Control and Prevention, the prevalence of dental cavities in Americans is again on the rise, suggesting a regression in the progress of combating this disease.

Taking inspiration from the body’s own natural tooth-forming proteins, the UW team has come up with a way to repair the tooth enamel. The researchers accomplished this by capturing the essence of amelogenin — a protein crucial to forming the hard crown enamel — to design amelogenin-derived peptides that biomineralize and are the key active ingredient in the new technology. The bioinspired repair process restores the mineral structure found in native tooth enamel.

Related: Heal Cavities, Gum Disease, Naturally with Organic Oral Care – Toothpaste recipes included

“These peptides are proven to bind onto tooth surfaces and recruit calcium and phosphate ions,” said Deniz Yucesoy, a co-author and a doctoral student at the UW.

The peptide-enabled technology allows the deposition of 10 to 50 micrometers of new enamel on the teeth after each use. Once fully developed, the technology can be used in both private and public health settings, in biomimetic toothpaste, gels, solutions and composites as a safe alternative to existing dental procedures and treatments. The technology enables people to rebuild and strengthen tooth enamel on a daily basis as part of a preventive dental care routine. It is expected to be safe for use by adults and children.

Co-authors are H. Fong, research scientist in the UW Department of Materials Science and Engineering, and Greg Huang, professor and chair of Orthodontics in the School of Dentistry.

In Hopes That Death ‘Might Serve Others,’ Lawyer and Human Rights Advocate David Buckel Burns Himself Alive in Fossil Fuel Protest

Prominent LGBTQ rights lawyer and environmental campaigner David Buckel died this weekend after self-immolating in an apparent protest against the destruction caused by greenhouse gas emissions.

“My early death by fossil fuel reflects what we are doing to ourselves,” wrote the prominent LGBTQ rights lawyer in a note before his death.

“Pollution ravages our planet, oozing inhabitability via air, soil, water and weather. Most humans on the planet now breathe air made unhealthy by fossil fuels, and many die early deaths as a result—my early death by fossil fuel reflects what we are doing to ourselves,” read  a note that was found near Buckel’s remains, in Prospect Park in Brooklyn, New York early on Saturday morning.

Buckel, who was 60 years old, added that he hoped his death “might serve others.”

The attorney ran Lambda Legal’s Marriage Project before the Supreme Court ruled in favor of marriage equality in 2015. He also steered the group’s efforts to fight for LGBTQ youths’ rights, winning a landmark victory in 1996 for a high school student who was forced to leave his school after administrators failed to protect him from brutal bullying.

Buckel also prosecuted Richardson County, Neb., which was found liable in the murder of Brandon Teena, a transgender teenager.

“The news of David’s death is heartbreaking,” said Camilla Taylor, director of constitutional litigation for Lambda Legal, in a statement. “This is a tremendous loss for our Lambda Legal family, but also for the entire movement for social justice…We have lost a movement leader, a colleague, and a friend. We will honor his life by continuing his fight for a better world.”

https://www.youtube.com/watch?v=4UQf8pHLVXQ

How to Detox Heavy Metals to Help End Exhaustion and Chronic Fatigue

Detoxification Treatment

Detoxification is an important aspect of optimal health, but can be quite confusing, not to mention risky if done incorrectly. Wendy Myers, a functional diagnostic nutritionist, founder of MyersDetox.com and author of “Limitless Energy: How to Detox Toxic Metals to End Exhaustion and Chronic Fatigue,” is a treasure trove of information on this topic.

One key component many fail to take into consideration when detoxing is their exposure to non-native electromagnetic fields (EMFs) and microwave radiation from cellphones and Wi-Fi routers. Unless you address these exposures, your detoxification capacity may be impeded. In other words, your body may not be able to excrete heavy metals as efficiently as it would otherwise, due to the interference caused by EMFs.

Related: Detox Cheap and Easy Without Fasting – Recipes Included

EMFs Hinder Detoxification

As explained by Myers, when you have heavy metals in your body, you tend to attract EMFs to your body. EMFs in turn impact your body’s metabolism and functioning — and its ability to effectively eliminate toxins and heavy metals.

“That is one of the things I work with,” Myers says. “Identifying and trying to reduce EMF in [my clients’] environment, so they can improve their body’s ability to function generally and to detox.”

In my book, “Fat for Fuel: A Revolutionary Diet to Combat Cancer, Boost Brain Power and Increase Your Energy,” I detail a program to improve your mitochondrial function, and reducing your toxic burden is an important part of the equation. Your mitochondria will suffer as long as you bombard your body with EMF. In fact, EMF exposure itself is intrinsically a mitochondrial poison.

Professor Emeritus Martin Pall wrote an excellent paper explaining one of the primary mechanisms of harm from exposure to microwave radiation from cell phones. It is related to voltage-gated calcium channels. EMFs impact these calcium channels that release calcium into the cell.

Calcium causes nitric oxide release and combines with superoxide, thereby creating perioxinitrate, which is a massive producer of f hydroxyl free radicals, the most destructive free radical known. Regular exposure to EMFs can actually poison your cells more than ionizing radiation from X-rays.

Common Metals That Wreak Havoc With Your Mitochondrial Function

Fatigue is a widespread problem today. “In doing my research, I was trying to figure out what is making us so tired,” Myers says. Eventually, she discovered a treasure trove of mitochondrial research and studies showing how various metals impact the mitochondria’s ability to produce adenosine triphosphate (ATP), the energy currency in your body. Metals that are particularly detrimental to mitochondrial function include:

Aluminum, which is very prevalent in our environment, including the air we breathe, thanks to geoengineering. Aluminum is also found in many vaccines, and is used in water treatment plants to separate out sediments. Antiperspirants, aluminum cans, foil and cookware are other common sources of exposure.

Related: Start Eating Like That and Start Eating Like This – Your Guide to Homeostasis Through Diet

Aluminum poisons enzymes that transport nutrients into your mitochondria, impeding their ability to produce energy. “When you remove aluminum and other mitochondrial poisons, we see a dramatic uptake in people’s energy levels, even people who are chronically fatigued or bedridden from their fatigue,” Myers says. “Within a year or so, they are able to start functioning again just from detoxing these metals”

Arsenic, found in antibiotics fed to conventionally-raised chickens and eggs, is another. To avoid arsenic, eat organic, pastured eggs and chicken. Rice is another common source, and Myers recommends avoiding brown rice for this reason. Other sources include wine, apple juice and drinking water

Tin affects your mitochondria a bit differently. The membrane of your mitochondria needs to have a certain charge to function properly. Tin dispels that charge, effectively handicapping the mitochondria. According to Myers, many have surprisingly high levels of tin in their bodies

Thallium, a gasoline additive, is a common air pollutant thanks to smog and car exhaust fumes. Thallium is added to gasoline for the same reason lead used to be added — to reduce knocking and improve engine performance. Lead was successfully removed from gasoline after public outcry, but now they add thallium instead. Few are aware of this, or understand its health effects, but thallium is a major factor in chronic fatigue

Related: Candida, Gut Flora, Allergies, and Disease

How to Test for Heavy Metals

There are a number of different ways to test for heavy metals, including hair, urine and stool. Certain metals, such as thallium, show up best in a urine dimercaptosuccinic acid (DMSA) challenge test. DMSA is a chelating agent that can be administered either orally or intravenously. When taken together with a synergistic agent like glycine, it binds to the metals in your body, forcing them out through your stool and urine.

Myers typically starts out doing a hair mineral analysis. It’s easy to do, relatively inexpensive and provides a significant amount of information. Ideally, you’ll want to do all three — hair, stool and urine tests — as no one test is perfect. Some metals come out in hair, others in urine and/or stool. Cadmium, for example, comes out in stool, so a stool test will be the most accurate.

“A lot of people have cadmium toxicity, so it’s very important to measure that,” Myers says. “A lot of people have mercury fillings, so we’ll see a lot of silver from those amalgams coming out in the stool as well. Those kill gut bacteria and cause gut dysbiosis … Other metals prefer to be excreted in the hair. That’s why I’d like to use all those different tests.”

No One Is Exempt From Heavy Metal Toxicity

I did a heavy metal analysis on hair, urine and stool, and despite leading a fairly clean lifestyle, I had every single one of these heavy metals in my body. So, I’m currently doing Myers’ detoxification program myself. While some believe detoxification is unnecessary and view such recommendations with suspicion, I believe accumulation of toxins is an unfortunate artifact of living in the 21st century.

Related: Gluten, Candida, Leaky Gut Syndrome, and Autoimmune Diseases

You’re continually exposed, so not only might you need to go through an aggressive detoxification program, but then you need to have some form of maintenance program to keep up with the continuous exposures.

“Yes, that’s my main message to people,” Myers says. “You should think of detox as a lifestyle, not something that you’re doing for 30 days, six months or even a year. It’s just something that you incorporate into your healthy lifestyle. We’ll talk about some of the supplements and detox protocols that you can do to facilitate that …  

I’m always surprised that my healthiest clients, like yourself, have a lot of metals coming out. Your body is working really well. You’re very healthy, so your body is able to excrete these metals much better than someone who is sick … or their detox organs aren’t functioning very well. But no one is exempt. Everyone has toxic metals in their body that we want to tend to if we plan to live a long, healthy, energetic and disease-free life.”

Indeed, because I lead such a healthy lifestyle, I thought I was somewhat immune to this kind of toxicity. I now suspect my arrogant ignorance of EMF exposure sabotaged my body’s ability to excrete these toxins. Now, I’m extremely diligent about avoiding EMF exposures, and I believe it’s having a positive effect.

Unfortunately, virtually no one, not even most detox experts, understand the EMF issue. I’m trying to change that by starting a dialogue about it. Because you can implement all of these detox strategies, but if you don’t radically reduce your EMF exposure, you’re merely spinning your wheels, investing time, energy and resources while limiting any potential benefit.

Related: Sugar Leads to Depression – World’s First Trial Proves Gut and Brain are Linked (Protocol Included)

Near- Versus Far-Infrared Saunas

Saunas are an excellent detoxification tool, and Myers is one of the few clinicians who actually understands the difference between regular infrared saunas, which use far-infrared and the near-infrared. Far-infrared helps accelerate removal of toxins through sweat, but near-infrared, in the range of 830 to 850 nanometers (nm) is especially important for improving mitochondrial function.

Delivering near-infrared light to the compromised mitochondria synthesizes gene transcription factors that trigger cellular repair. So, ideally, you’ll want to use a full-spectrum sauna. At present, those are hard to find, but you can modify you far-infrared sauna by adding a near-infrared light in the 830 to 850 nm range to it. Myers explains:

“Infrared saunas are one of the best ways to detox your body. I recommend them to all my clients … [T]he most common sauna is a far-infrared sauna … I’m a big fan of near-infrared saunas also.

There are near-infrared bulbs saunas, which are fine for detoxification, but you want to add more concentrated near-infrared energy. You can do that with near-infrared light emitting diodes (LEDs). The best detox combo is a far-infrared sauna with a near-infrared LED and a red LED panel inside of it. That’s the best combo.”

Other Sauna Considerations

Another important consideration when looking for an infrared sauna is to make sure it’s a low-EMF version, as many will emit very high amounts of extra-low frequency EMFs. So, look for manufacturer specifications on EMF emissions. As a general recommendation, avoid the really cheap ones made in China. In addition to EMFs, many of those made with inexpensive materials contain glue and particle board that emit volatile organic compounds (VOCs).

Some recommendations call for constructing your own near-infrared sauna using four 250-watt heat lamp bulbs. Most of the energy they produce is in the mid- and far-infrared range, with only 10 percent or so in the near-infrared. The drawback is that the radiation tends to decrease rapidly the further you get from the bulb, and you cannot get too close to the bulb because it’s so hot you’ll burn yourself. As a result, you’re getting mostly far-infrared even from these bulbs.

I prefer Myers’ recommendation, which involves using infrared LEDs, as they generate very little heat, so you can put them very close to your body, right where you need it. Myers explains:

“The near-infrared LEDs are something that have been available in the last few years. There are amazing companies making products like these, the near-infrared and red LED combo products that you can add to your near-infrared bulb sauna or far-infrared sauna. That’s the way that I would go if you’re looking for that maximum detox effect.”

Sauna Recommendations for Detoxification

Contraindications for sauna use include having a pacemaker or metal implants in your body, as they may be heated by the infrared rays. Most people with metal pins in their body will not experience any problems, but it’s something to be mindful of. Saunas are also generally contraindicated for children under the age of 7.

“Their temperature regulation system doesn’t quite work well enough, so I would not have a child use an infrared sauna,” Myers says. “As far as how to use a sauna, I recommend people do them three to five days a week, starting with about five to 10 minutes.

If you’re really, really ill, you’d want to start with a low amount and then slowly work your way up; like maybe each week add a couple of minutes to your sessions. You ought to do what works for you. It doesn’t matter what I say or what I recommend. I want you to listen to your body and do what works for you. If you start to feel nauseated, lightheaded or unwell in any way, it’s time to get out of the sauna.”

Dry brushing your skin prior to the sauna is also helpful as it will get your lymph moving. Then, as soon as you get out of the sauna, be sure to shower right away. The last thing you want is for those excreted toxins to dry out on your body after you’ve sweated them out.

Related: Holistic Guide to Healing the Endocrine System and Balancing Our Hormones

I will typically jump into my pool right afterward. The water being a cool mid-40s in the winter to 80s in the summer, it gives me the added advantage of cold thermogenesis in the winter, but also helps remove the toxins excreted through the skin in my sweat. Also be sure to use some kind of binder when detoxing in a sauna. You need something to mop up all the toxins mobilized from your tissues to keep them from your vital organs.

The Importance of Magnesium

Myers also has an online program called “Mineral Power,” which focuses on replenishing minerals lost during the detoxification process.

“There’s always a cost to any kind of detox protocol you do,” Myers says… But the benefits far outweigh the cost. We’re willing to sacrifice some minerals for the benefits. But there are other minerals, like magnesium, which 80 percent of people are estimated to be deficient in. Magnesium is incredibly important to facilitate all of your body’s enzymatic processes, your metabolism … including facilitating detoxification.”

Earlier I mentioned the importance of avoiding EMF as it affects your voltage-gated calcium channels. In studies on calcium channel blockers, researchers discovered these medications mitigated and nearly eliminated the EMF effects. Now, magnesium is a calcium channel blocker, which means that not only will magnesium help your detoxification process if you’re deficient, but it may also remediate some of the inevitable EMF exposure we’re all subject to.

“I can’t tell you how many clients have told me that they just started taking magnesium alone and they start feeling better within a week or so,” Myers notes. “I had the same experience when I did my first hair tissue mineral analysis a long time ago. I started taking magnesium. I couldn’t believe how much better I was feeling. I had to become a practitioner and tell more people about this, about the importance of minerals.”

The Importance of Zinc

Zinc is another important mineral required for detoxification. Minerals help push out metals, as many metals bind to receptors that would normally be occupied by minerals. When you’re deficient, metals can easily take the minerals’ rightful place. Zinc helps push out cadmium, a metal that causes more cancers than all of the other metals combined. Myers explains:

“This is why cigarette smokers get cancer. It’s why my dad got esophageal cancer. He smoked for 40 years … [Y]ou get cadmium from cigarettes … our environment [air] … shellfish and fish. It’s not only mercury that’s in fish. It’s cadmium as well. Cadmium interferes when DNA copies. When a cell multiplies or divides, cadmium interferes in the DNA copying properly, so you get this mutated cell.

We have about 100 million cancer cells in our body at any one time. But if your immune system is malfunctioning, say it’s damaged by metals, EMF or it’s nutrient-deficient or just doesn’t have the energy to function, that’s when that mutated cell caused by cadmium will be allowed to grow and manifest into a tumor, be it malignant or benign. That’s the mechanism by which cadmium causes cancer.”

Cadmium is also a significant contributor to hardening of the arteries. If you are zinc deficient, your body is forced to accumulate cadmium to repair the arteries. However, cadmium is hard and brittle, so when it deposits into your arteries, it reduces the arteries’ ability to expand and to contract, thereby contributing to high blood pressure and heart disease.

This is also the mechanism by which smoking leads to heart disease. The good news is you can reverse this process by taking proactive steps to remove cadmium from your system. It is a slow, long process, however.

Other Important Minerals

Other important minerals include:

Selenium. Most people have insufficient levels of selenium, and you need this mineral to repair chromosome damage. Selenium is also needed for the conversion of thyroid hormone, from T4 to T3. You need it to make glutathione in your body — a master antioxidant made by your liver that is important for heavy metal detoxification.

Selenium also prevents viral replication, and helps detoxify arsenic, beryllium, cadmium, mercury and silver. The daily recommended dose is 200 micrograms (mcg) per day.

Potassium, while not a primary detox mineral, does help push out thallium.

Iodine can also be beneficial. Thyroid disease is extremely common, especially in those drinking fluoridated water, as fluoride displaces iodine. Chlorine and bromine also displaces iodine, and they too are added to your water supply and/or food. Iodine helps push out halogens that compete with iodine uptake in the thyroid. To facilitate detoxification of halogens, you will need to take much higher amounts of iodine than typically recommended for general health.

All these supplements are classified as Generally Recognized As Safe (GRAS), so there are no toxicity concerns. One exception is selenium. You do not want to take excessive amounts of it, and it has a very low therapeutic ratio. So, don’t take more than the recommended 200 mcg per day. More is not better in this case.

Where to Find Detox Help

Wendy is currently working on starting a detox institute, scheduled to open in 2018. She’s partnered with Dr. Bruce Jones to develop and legitimize hair mineral analysis. The Institute will teach medical doctors, licensed professionals and laypeople the science behind the use of hair mineral analysis.

“To date, most of what you learn about hair mineral analysis doesn’t have a scientific backing to it. What we want to change, and what I want to do, is really legitimize it in the eyes of the medical profession. We’re going to accomplish that by [making sure that] everything we say is backed by scientific research. You can look forward to that in 2018.”

If you would like to schedule an appointment with one of Myers’ personally trained Mineral Power practitioners, visit MineralPower.com.

“That’s where you can learn all about our detoxification program. It’s really a healing program as well. I wake up every day so excited to teach people about the importance of detoxification and how metals are affecting their body, because they’re not getting that information from their conventional medical doctor.

They go to their doctor and maybe they’re getting advised to take medications or surgery, which is useful in many situations. But there’s a big absence of information into the underlying root causes of people’s health issues, which are mineral and nutrient-deficiency, metal and chemical toxicities, EMF and other factors. I really want to educate people what they’re missing in trying to reach their health goals,” Myers says.

… It can really help to have someone holding your hand and getting support if you run into a road block or a problem with detoxification. Sometimes, there is preliminary work we have to do to get someone to the point where they’re able to detox … We help to troubleshoot what those issues are and develop a really individualized detox program to get your body where you want to get it.”

Myers’ book, “Limitless Energy: How to Detox Toxic Metals to End Exhaustion and Chronic Fatigue,” goes into these and many other details not covered in this interview. At $6 for the electronic version, it’s an absolute steal. If there’s a specific toxin you’re concerned with, Myers’ book will help you identify the different sources and the specific strategies you can use to eliminate it.

Also consider getting a high quality, low-EMF infrared sauna, and use it regularly in combination with these binders and any minerals you may be in need of. We live in a very toxic world. Even if you think you’re doing most everything right, chances are you have accumulated heavy metals in your body, which may prevent you from experiencing peak health.

Merger From Hell Approved By DOJ, Warnings Of Agrichemical Chokehold On Food System

(NaturalBlaze by Andrea Germanos) Watchdog groups sounded alarms on Monday after the Wall Street Journal reported that the proposed mega-merger of Bayer and Monsanto has cleared its final regulatory hurdle in the United States.

The reported approval from the Justice Department came “after the companies pledged to sell off additional assets,” the Journalreported, and despite concerns raised by hundreds of food and farm groups. It also comes weeks after the European Commission gave its thumbs up.

Related: Understanding and Detoxifying Genetically Modified Foods

“The approval of the third supersized seed merger, after ChemChina-Syngenta and Dow-DuPont,” said Wenonah Hauter, executive director of Food & Water Watch, “leaves farmers vulnerable to price gouging for seeds and other supplies and strengthens the hold a few dominant corporations have over the entire food system.”

“The Justice Department’s rubber stamping of these three seed mega-mergers transforms the already concentrated agrichemical and seed market, effectively reducing the number of competitors from six to three,” she added.

Because it will make it harder for farmers to acquire non-genetically modified seeds to plant, it “makes it harder for agriculture to get off the GMO-chemical treadmill that just keeps increasing in speed,” she said.

With its reported stamp of approval, the pending merger shows that “the federal government is not taking the impact of corporate control of our food supply seriously. It’s time for Congress to establish a moratorium on mega-mergers in the food system,” Hauter argued.

Related: Foods That Are GMO

Jason Davidson, food and technology campaign associate with Friends of the Earth, was equally critical in his reaction to the development.

“The Department of Justice has decided that corporate profits matter more than the interests consumers and farmers. This decision will massively increase the power of major agrichemical companies that already have a stranglehold on our food system,” he declared in a statement.

He went on to lament that “American farmers will see increased seed prices, fewer options, and decreased bargaining power.” Echoing Hauter’s warning, he argued. “This merger from hell will further entrench the failing model of toxic, chemical-intensive agriculture, which is poisoning people and the planet.”

Related: Doctors Against GMOs – Hear From Those Who Have Done the Research

A recent poll found that nearly 94 percent of farmers expressed concern that a Bayer-Monsanto merger would have a negative impact on independent farmers and their communities. It also found that 89 percent of farmers said they believe the merger would lead to increased pressure for chemically-dependent farming.

Berberine May Ease Symptoms of Anxiety and Depression — And Much More

(Dr. Mercola) Berberine — a yellow-colored alkaloid compound found in several different plants, including European barberry, goldenseal, goldthread, Oregon grape and tree turmeric — has antibacterial, anti-inflammatory, antiproliferative, antidiarrheal, antineoplastic, antidiabetic and immune-enhancing1 properties. It has a long history of use in traditional medicine, including traditional Chinese medicine, and many of its historical uses now have scientific backing.

For example, it’s effective against a wide range of bacteria, protozoa and fungi, and is commonly used to treat gastrointestinal issues, including traveler’s diarrhea and that from food poisoning. Having similar mechanisms of action as the drug metformin, berberine can also be used as an oral hypoglycemic for Type 2 diabetics.

Related: Berberine

It’s helpful against seasonal allergies and even helps combat metastatic stem cells and heart failure. Many integrative health practitioners swear by berberine as a general health supplement due to its ability to address such a wide variety of maladies.2 As noted by Dr. Michael Murray:3

“… I think [berberine] is poised to be the biggest thing in the natural product industry … Here is why: Berberine has been shown to:

  • Produce results in clinical trials in improving Type 2 diabetes on par or better than conventional drugs including metformin.
  • Improve blood lipid levels better than statins.
  • Lower blood pressure in many subjects as well as any class of antihypertensive medication.
  • Improve liver function and promote anti-obesity effects.
  • Exert significant beneficial effects on digestive health and the microbiome.
  • Produce very encouraging experimental data in a wide range of modern health issues including cancer, Alzheimer’s disease, Parkinson’s disease and others.”

What Makes Berberine Such a Powerful Remedy?

Many of berberine’s health benefits4 have been linked to its ability to activate adenosine monophosphate-activated protein kinase (AMPK).5 AMPK is an enzyme inside your body’s cells. It’s sometimes referred to as a “metabolic master switch” because it plays an important role in regulating metabolism.6

Related: Insomnia – A Comprehensive Look with Natural Remedies

Low AMPK has been linked to insulin resistance, mitochondrial dysfunction, obesity, neurodegeneration and chronic inflammation — all of which lay the groundwork for a wide variety of serious chronic diseases. In an article discussing the clinical uses of berberine for metabolic syndrome and Type 2 diabetes, the Natural Medicine Journal highlights its effect on AMPK:7

“AMPK induces a cascade of events within cells that are all involved in maintaining energy homeostasis… AMPK regulates an array of biological activities that normalize lipid, glucose and energy imbalances. Metabolic syndrome occurs when these AMPK-regulated pathways are turned off, triggering a syndrome that includes hyperglycemia, diabetes, lipid abnormalities and energy imbalances …

AMPK helps coordinate the response to these stressors, shifting energy toward cellular repair, maintenance or a return to homeostasis and improved likelihood of survival. The hormones leptin and adiponectin activate AMPK. In other words, activating AMPK can produce the same benefits as exercise, dieting and weight loss — the lifestyle modifications considered beneficial for a range of maladies …

One way to appreciate berberine’s potential is to think of it as having the same effect on a patient as increasing exercise while at the same time restricting calorie intake. Think of the effects of AMPK suppression as similar to those of eating a high-calorie diet while leading a very sedentary lifestyle.”

Berberine Helps Ease Anxiety and Depression

AMPK is also an important neuroprotector. As explained in the Journal of Neurochemistry,8 “AMPK senses metabolic stress and integrates diverse physiological signals to restore energy balance. Multiple functions are indicated for AMPK in the [central nervous system] …” Berberine also benefits brain health and psychological well-being by increasing key neurotransmitters.

Related: Holistic Guide to Healing the Endocrine System and Balancing Our Hormones

A number of studies have demonstrated berberine’s usefulness against anxiety and depression, in part by inhibiting monoamine oxidase, an enzyme that breaks down serotonin, noradrenaline and dopamine in your brain. These neurotransmitters play important roles in mood and have been implicated in depression.

An Indian study9 published in 2008 confirmed berberine has antidepressant effects, reversing “behavioral despair” in stressed rats. Interestingly, the effects were not dose-dependent. Even low doses had a beneficial effect. According to the authors:

“Berberine (5 mg/kg, i.p.) following its acute administration in mice resulted in increased levels of norepinephrine (31 percent), serotonin (47 percent) and dopamine (31 percent) in the whole brain. Chronic administration of berberine (5 mg/kg, i.p.) for 15 days significantly increased the levels of norepinephrine (29 percent), serotonin (19 percent) as well as dopamine (52 percent) …

[A]t higher dose (10 mg/kg, i.p.), there was no change in the norepinephrine (12 percent) levels but a significant increase in the serotonin (53 percent) and dopamine (31 percent) levels was found.”

A similar study by South Korean researchers found berberine was helpful in treating post-traumatic stress disorder (PTSD). As in the Indian study, rats exposed to prolonged stress exhibited significantly reduced anxiety-driven behaviors after receiving berberine. They were also better able to complete complex navigational tests.

Most remarkable of all, berberine was shown to “restore the main neurochemical abnormalities in the brains of rats in the PTSD model” — a rather surprising effect that “supports a central mechanism of action that berberine heals brains damaged by severe stress or fear.”10

Berberine Eases Side Effects Associated With Drug Withdrawal

Berberine has also been shown to activate Sigma1 receptors, a subclass of opioid receptors that react to morphine and similar substances — including those produced naturally in your body — and inhibits glutamate, thereby improving anxiety and depression.11Sigma1 receptors play a role in oxidative stress, the functioning of your nervous system and the survival of neurons, and as such are believed to influence neuropsychiatric problems, including psychotic conditions.12

Related: Natural Remedies for Depression

A study13 published in the Korean Journal of Physiology and Pharmacology assessed berberine’s effect on not just depression and anxiety but also on the noradrenergic system. Here, they used morphine-addicted rats to see whether berberine might ease morphine withdrawal — symptoms of which often include depression and anxiety. As explained by the authors:

“Male rats were exposed to chronic, intermittent, escalating morphine (10~50 mg/kg) for 10 days. After the last morphine injection, depression- and anxiety-like behavior associated with morphine discontinuation persisted for at least three days during withdrawal without any change in ambulatory activity. Daily berberine administration significantly decreased immobility in the forced swimming test and increased open-arm exploration in the elevated plus maze test …

Taken together, these findings demonstrated that berberine administration significantly reduced morphine withdrawal-associated behaviors … possibly through modulation of hypothalamic corticotrophin-releasing factor and the central noradrenergic system. Berberine may be a useful agent for treating or alleviating complex withdrawal symptoms and preventing morphine use relapses.”

Berberine Supports Gut Health and Much More

Berberine has also been shown to support a healthy gastrointestinal tract and microbiome in a number of different ways, and this too can have a beneficial impact on your mood and mental health. There’s ample research showing your gut health plays a very important role in your brain health, and can influence your mood for better or worse. As for improving your gut health, studies have shown berberine helps:

Prevent diarrhea by delaying the amount of time it takes for food to pass through your small intestine14
Lower your risk of leaky gut15
Protect against gut damage caused by high alcohol consumption16
Lower intestinal inflammation caused by inflammatory cytokines17
Preferentially nourish microbes that produce beneficial short-chain fatty acids, known to have many health benefits18
Improve symptoms of fatty liver disease by normalizing the gut microbiome19
The normalization of gut bacteria also resulted in lower body weight, lower serum levels of lipids, lower glucose and insulin levels, and the normalization of insulin resistance20

Drug Interactions

While berberine is quite safe and well-tolerated, it may be contraindicated if you’re taking medications.21 For example, berberine may hinder absorption of tetracycline and other similar antibiotics, rendering them ineffective. Also, because berberine significantly inhibits CYP3A enzymes — enzymes needed to metabolize most drugs — it can lower the clearance of medications, which in turn can augment their effect. This can lead to overdose, the risks of which will vary depending on the drug in question.

Related: Sugar Leads to Depression – World’s First Trial Proves Gut and Brain are Linked (Protocol Included)

Berberine inhibits CYP3A just like curcumin, which impairs phase 2 detoxification, where your body makes toxins water soluble so they can be excreted. So, this would not be supplements to use during fasting where you have large lipolysis and liberation of stored toxins that need to be metabolized.

Because of all its benefits, I have been taking berberine for over two years. However, because it is a potent alkaloid, I believe it needs to be cycled. So, I take it for a week then take a week off. Alternatively, you can skip it on the weekends. The general principle is cycling, just like one does with the ketogenic diet. It is not wise to be continuously ketogenic.

Also, as noted by Murray:22 “Berberine … enhances the effects of oral hypoglycemic drugs used in the treatment of Type 2 diabetes through its multitude of antidiabetic effects. People on oral hypoglycemic drugs should monitor blood glucose levels if taking berberine and adjust their dosage of their medications as needed and under the care of a medical professional.” I tell virtually everyone taking metformin to switch to berberine as it is far safer.